Adaptive Liver: From Health to Disease
What we do
The Alcedo Lab studies why and how tissues adapt to dynamic environmental changes to inform us on how diseases begin and what drives disease progression. We use the liver as a model organ because it undergoes repeated cycles of injury and repair, rendering it exceptionally resilient for a long period.
Why we do it
Understanding the complexities of the liver is essential for addressing the urgent and widespread challenge affecting millions of patients worldwide who suffer from chronic liver diseases such as alcoholic liver disease, metabolic-associated fatty liver disease, and liver cancer. Many of these individuals are often diagnosed late, hampering effective treatment.
How we do it
Our research focuses on studying tissue resilience using mouse and human liver organoids as our model system. To systematically analyze how the liver adapts and how disease progresses, we perform a variety of methods including biochemical, genetic, histological, and molecular approaches