Adaptive Pathogenesis of Liver Diseases
What we do
The Alcedo Lab studies the liver to advance strategies for disease detection and early therapeutic intervention. The liver undergoes repeated cycles of injury and repair, rendering it an exceptional model organ to study why and how diseases actually begin, and what drives disease progression.
Why we do it
Understanding the complexities of the liver is essential for addressing the urgent and widespread challenge affecting millions of patients worldwide who suffer from chronic liver diseases such as alcoholic liver disease, metabolic-associated fatty liver disease, and liver cancer. Many of these individuals are often diagnosed late, hampering effective treatment.
How we do it
Our research focuses on studying liver biology through the use of cell-based and rodent models. We utilize a variety of methods including biochemical, genetic, histological, and molecular approaches to systematically analyze how the liver adapts and how liver disease progresses.